Today seven scientists are up to $500,000 minus tax richer for having won this years Shaw Prizes.

## Astronomy

First up are Enrico Costa and Gerald J Fishman for leading the NASA mission that resolved the origin of gamma ray bursts. It does not seem to many years ago since gamma-ray bursts were regarded as one of the great unsolved mysteries of science. They had first been detected in 1967 by the Vela satellites which had been placed in orbit by the US military to check that the USSR was not detonating nuclear weapons in contravention of the 1963 partial test ban treaty. Nuclear explosions would send gamma rays into space where the satellites would detect them. Instead they observed gamma ray bursts coming from space.

From 1973 when their existence was declassified until 1997, these events were so mysterious that astronomers could not even tell if they came from nearby in our galaxy or billions of years away across the universe. NASA launched the BeppoSAX satellite to try to resolve the question, In 1997 it observed a powerful gamma ray burst which left an afterglow long enough for Earth based telescopes to lock onto its location just 8 hours later. Now they could see that it came from a very distant galaxy.

The gamma rays are so bright at that distance that it is inconceivable that they are being radiated equally in all directions in such a short space of time. The amount of energy that would have to be concentrated into a small volume is juts not possible. It is thought that they come from energetic supernovae with a rapidly rotating remnant that focuses the gamma rays into a tight beam. we only see the burst for the small fraction of events where we happen to lie in the direction of the ray.

## Life Science and Medicine

Next were Jules A Hoffmann, Ruslan M Medzhitov and Bruce Beutler for uncovering the biological mechanisms for innate immunity. When an animal or plant is infected it deploys a number of mechanisms to defend itself. One of the first is the innate immune system, thought to be one of the earliest mechanisms to evolve because it is so widespread across diverse forms of life. In plants it remains the dominant immune system, but advanced animals have developed more effective systems of adaptive immunity that can change to attack specific viruses or other contagents.

Understanding all forms of immunity is vital to medicine because it provides the knowledge needed to find drugs that help us fight diseases.

## Mathematics

Finally, Demetrios Christodoulou and Richard S Hamilton won the mathematics prize for work on differential manifolds with implications for general relativity and the Poincaré conjecture.

When Grigori Perelman famously turned down the Fields medal and the million dollar Clay prize for resolving the Poincaré conjecture, he said that his reason was that other mathematicians such as Richard Hamilton has contributed just as much to the proof. He need not have been so concerned since Hamilton has now himself been recognized with a lucrative award.

It was Hamilton who discovered the theory of Ricci flow on differential manifolds that lead Perelman to his proof of the Thurston geometrization conjecture that was known to imply the truth of the Poincaré conjecture, a mathematical problem that had remained unsolved for a hundred years.

Demetrios Christodoulou is a mathematical physicist who worked for his doctorate at Princeton under the direction of John Wheeler. He is known for his extraordinarily difficult proof of the unsurprising fact that flat empty Minkowski space is stable under the action of nonlinear gravitational dynamics as described by general relativity.